With the European Championship less than two weeks away, Spain showed they are in good shape to defend the title by beating Serbia 2-0 in their first warmup game.
It wasn't such a successful night for two more of the continent's heavyweight sides, however, with a Germany team missing its Bayern Munich stars losing 5-3 in Switzerland and the Netherlands losing 2-1 to Bulgaria.
Germany and the Netherlands are in the same Euro 2012 group, along with Portugal, which drew 0-0 with Macedonia, and Denmark, who were beaten 3-1 by Brazil.
But Roy Hodgson began his reign as England manager with a 1-0 victory at Norway.
The friendlies give Euro 2012 contenders a chance to assess their lineups just two weeks before the tournament starts in Poland and Ukraine.
Adrian Lopez made a case for starting up front for the Spanish at the Euros in place of the injured David Villa by opening the scoring in the 64th minute on his international debut, before earning the penalty that was converted by Santi Cazorla 16 minutes from time.
Adrian was one of six players introduced after the break by coach Vicente del Bosque, who was without his star names from Barcelona, and they helped turn the game the world champions' way in St. Gallen, Switzerland.
The Atletico Madrid striker finished off a quick counterattack by heading home Jesus Navas' cross after the winger was released from a long ball by substitute Benat Etxebarria.
Adrian, the leading scorer in Spain's win in the Under-21 European Championship last year, was then felled by Branislav Ivanovic, allowing Cazorla to step up to score from the spot.