Lack of exercise can lead to fatty liver disease

Hepatic steatosis is a reversible condition that causes fat to accumulate in liver cells of obese people.

The new study by researchers at University of Missouri indicated that a regular exercise could prevent nonalcoholic fatty liver disease, which affects at least 75 per cent of obese people.

"We found that the cessation of daily exercise dramatically activates specific precursors known to promote hepatic steatosis," said Jamal Ibdah, professor of medicine and medical pharmacology and physiology in the MU School of Medicine.

He added: "This study has important implications for obese humans who continually stop and start exercise programs. Our findings strongly suggest that a sudden transition to a sedentary lifestyle increases susceptibility to nonalcoholic fatty liver disease."

After 173 hours, or about seven days, scientists observed that the rats began showing signs of factors responsible for promoting hepatic steatosis.

In case of the animals tested immediately at the end of 16 weeks of voluntary running, researchers noted no signs of hepatic steatosis.

"Physical activity prevented fatty liver disease by 100 per cent in an animal model of fatty liver disease. In contrast, 100 per cent of the group that did not have physical activity had fatty liver disease. This is a remarkable event. It is rare in medicine for any treatment to prevent any disease by 100 per cent," said Frank Booth, a professor in the MU College of Veterinary Medicine and the MU School of Medicine.

The study, titled "Cessation of Daily Exercise Dramatically Alters Precursors of Hepatic Steatosis in Otsuka Long-Evans Tokushima Fatty (OLETF) Rats," was published in The Journal of Physiology.