A Taliban spokesman, Maulvi Umar, denied the report. Pakistan army and intelligence officials said they had no information that al-Zawahri was hit.
Both bin Laden and al-Zawahri are believed to be hiding in the rugged and lawless tribal regions along the Afghan-Pakistan border.
In January, al-Masri was initially reported to have been killed in a similar airstrike said to have been targeting al-Zawahri, but Pakistani officials quickly backed off claims al-Masri was killed.