Infections may speed up memory loss in Alzheimer’s

this protein.

It is possible that finding a way to reduce inflammation “could be beneficial for people with Alzheimer’s disease,” said study chief Dr Clive Holmes from the University of Southampton,UK.

For over six months,Holmes and colleagues measured the cognitive abilities and blood levels the inflammatory protein TNF-alpha of 222 people with Alzheimer’s disease.

During the follow-up,roughly half the subjects experienced a sudden infection or injury that led to inflammation,and a spike in TNF-alpha levels. These people,the researchers found,experienced memory loss that was twice of those who did not have infections or injuries.

People who had high levels of TNF-alpha in their blood at the beginning of the study — a sign of chronic ongoing inflammation — had memory loss at four times the rate of those with low levels of the protein at the start of the study.

By contrast,subjects with low levels of TNF-alpha throughout the study showed no decline in brain function,the report indicates.

“One might guess that people with a more rapid rate of cognitive decline are more susceptible to infections or injury,but we found no evidence to suggest that people with more severe dementia were more likely to have infections or injuries at the beginning of the study,”

Holmes said.